As stipulated in the Newborn Screening Act of 2004, the NSRC shall be guided by the following functions:

• be responsible for the national testing database and case registries, training, technical assistance and continuing education for laboratory staff in all Newborn Screening Centers
• define the testing and follow-up protocols for Newborn Screening Centers (NSCs) to be established in strategic locations in the country
• maintain an external laboratory proficiency-testing program
• oversee the national testing database and case registries
• report to the BHFS the NSCs found violating these rules and regulations and those performing and providing NBS procedures and services without any DOH accreditation
• participate in consultation and evaluation activities initiated by BHFS in relation to the NSRC and the NSCs performance and in improving implementation of these rules and regulations.